![]() Since all RADT-positive / RTPCR-negative samples were reported from 2 centers, it would be interesting to study the S and N gene mutations by analyzing the whole genome sequencing data of SARS CoV-2 strains from these geographical areas during the study period. Variants keep on emerging during an pandemic especially in immunocompromised patients and those variants not fit for long term survival are eliminated by process of natural selection. Preliminary results of the rapid assessment conducted by UK’s NHS and Foundation for Innovative New Diagnostics (FIND) suggest that the accuracy of RADTs has not been impacted by the emergence of the Delta or Omicron variant. As a majority of Delta variant (B.1.617.2) mutations occur in S gene and other open reading frames (ORF), there are high chances that detection of these variants is missed by RTPCR targeting S/ORF genes, making RTPCR and less accurate reference standard. The authors assume that all RADT-positive/RTPCR-negative samples are false positives (42%).Īn important technical point missing from the discussion is that RADTs are mainly targeted at detecting the viral nucleocapsid protein coded by the N gene which in the Delta/ Omicron variant appears less divergent than the S gene expressing spike protein. This study reports that 1103 health care workers were RADT positive and that corresponding RTPCR was positive only in 641 (58%) cases. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine. ![]() Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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